Our Technique

The O in PDOX stands for orthotopic. In Greek, that means “the correct place.”

PDOX stands for Patient Derived Orthotopic Xenografts.

Our pioneering technique is called Surgical Orthotopic Implantation (SOI). We have found that placement of the patient’s tumor in the corresponding location in the mouse – the orthotopic or correct location – provides the closest tumor behavior to the patient.  Further, it’s the only technique that reliably metastasizes.

This process enables the concurrent testing of multiple drugs in multiple mice against metastasis, which is the lethal aspect of cancers, as well as against the primary tumor.  This increases the accuracy, effectiveness and timeliness of treatment of the patient’s cancer.

Certis Oncology has an 80% success rate of tumor growth and approximately a 3 months median interval to treatment recommendation. Solutions currently on the market offer less than a 50% success rate and more than 6 months to treatment, with mouse models that do not enable metastasis.

Visualization Techniques

Additionally, the PDOX solution suite includes advanced fluorescence-based visualization tools that enable scientists to observe tumor behavior in the mouse models in real-time.  These tools enable the scientist to clearly see the following:

  1. Real-time metastasis, tumor growth and progression;
  2. Angiogenesis, which is the formation of new blood vessels; and
  3. Interactions of cancer cells with stromal cells, which control cancer cell growth and metastasis.

For more information on our orthotopic and visualization techniques, please contact us.